Detalhe da pesquisa
1.
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
PLoS Pathog
; 18(10): e1010926, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306287
2.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
3.
Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing.
Antimicrob Agents Chemother
; 66(1): e0116321, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34694871
4.
Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity.
bioRxiv
; 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712185
5.
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets.
bioRxiv
; 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38260474
6.
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology.
mBio
; 15(1): e0183223, 2024 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38059639
7.
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Eur J Med Chem
; 270: 116354, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38554474
8.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Nat Commun
; 15(1): 937, 2024 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38297033
9.
Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum.
ACS Infect Dis
; 9(10): 2036-2047, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712594
10.
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum.
Nat Commun
; 14(1): 3059, 2023 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37244916
11.
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
J Med Chem
; 66(5): 3540-3565, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812492
12.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
bioRxiv
; 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398288
13.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Sci Adv
; 9(45): eadi2364, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37939186
14.
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.
Cell Chem Biol
; 30(5): 470-485.e6, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36963402
15.
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Nat Commun
; 14(1): 1455, 2023 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36927839
16.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Res Sq
; 2023 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37546892
17.
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.
ChemMedChem
; 17(22): e202200393, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36129427
18.
Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study.
Lancet Infect Dis
; 22(6): 879-890, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35247321
19.
A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.
Nat Commun
; 13(1): 5746, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36180431
20.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Cell Chem Biol
; 29(5): 824-839.e6, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233174